5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer
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چکیده
منابع مشابه
5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer
Aims 5-FU is used as the main backbone of chemotherapy regimens for patients with colorectal and other gastrointestinal cancers. Despite development of new strategies that allowed enhancing clinical effectiveness and tolerability of 5-FU, 10-30% of patients treated with 5-FU-based regimens experience severe treatment-related toxicity. In our study, we evaluated the 5-FU exposure-toxicity relati...
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Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e. neutropenia, diarrhea or cardiotoxicity, the knowledge of 5-FU serum levels might help to attribute these sid...
متن کاملPsychological status in Head and Neck Cancer Patients with Xerostomia due to Radiotherapy
Background and objective: Psychological status is one of the quality of life (QOL) domains which can be affected by hyposalivation caused by head and neck radiotherapy. This study aimed to evaluate the psychological status of head and neck cancer (HNC) patients who were suffering from hyposalivation after at least one week of receiving radiotherapy. Material And Method: This descriptive-analyt...
متن کاملQuality of Life in Head and Neck Cancer Patients with Xerostomia due to Radiotherapy
Background and Aim: Head and neck cancers (HNC) and their treatment can cause short-term and long-term impairment in patient’s quality of life (QOL). The aim of this study was to evaluate QOL in HNC patients suffering from xerostomia due to radiotherapy. Material and Methods: This Descriptive analytical study was performed on 44 HNC patients suffering from xerostomia experiencing radiotherapy f...
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Introduction: Globally, intensity-modulated radiation therapy (IMRT) is considered as highly precise and accurate method of radiotherapy planning. This technique amplifies spatial dose distribution conformity by modulating the intensity of radiation beams in each sub-volume. Additionally, it can reduces the dose to surrounding critical organs and deliver the planned dose to targets with the nom...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1989
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1989.59